Drug Dependence and Synaptic Plasticity
نویسندگان
چکیده
منابع مشابه
Drug dependence, synaptic plasticity, and tissue plasminogen activator.
The mesocorticolimbic dopaminergic system plays an important role in the reinforcing effects of drugs of abuse, and the activity-dependent synaptic plasticity of the system is involved in drug dependence. A DNA microarray screening revealed that the expression levels of tissue plasminogen activator (tPA) mRNA in the nucleus accumbens of morphine- or methamphetamine-dependent rats were significa...
متن کاملsynaptic neuronal plasticity
context the current study aimed to review research articles concerning cortical representational plasticity following the manipulations of inputs. evidence acquisition this review article compromised previous studies in pubmed, google scholar and scientific information databases according to the keywords since 1988. results ca1 neurons depolarization paired with ca3 presynaptic input result in ...
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Introduction The clinical manifestations of drug addiction are the subject of medical literature and fiction alike. In Novel with Cocaine, first published almost 80 years ago under a pseudonym and only recently rediscovered, Mark Levi provides a disturbing account of a young Russian man becoming addicted to cocaine. Vadim, the novel’s antihero reflects: “Before I came in contact with cocaine I ...
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A primary feature of drug addiction is the compulsive use despite negative consequences. A general consensus is emerging on the capacity of addictive substances to co-opt synaptic transmission and synaptic plasticity in brain circuits which are involved in reinforcement and reward processing. A current hypothesis is that drug-driven neuroadaptations during learning and memory processes divert t...
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ژورنال
عنوان ژورنال: Journal of Alcoholism & Drug Dependence
سال: 2013
ISSN: 2329-6488
DOI: 10.4172/2329-6488.1000e103